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Chemical Structure : JTP-117968
Catalog No.: PC-61852Not For Human Use, Lab Use Only.
JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.
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JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.
JTP-117968 shows highly selective and GR binding affinity, has neither agonist nor antagonist activity against MT receptors.
JTP-117968 exhibits improved transrepression/transactivation dissociation not only in in vitro assays, but also in in vivo mice experiments.
| M.Wt | 520.596 | |
| Formula | C31H31F3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kurimoto T, et al. Eur J Pharmacol. 2017 May 15;803:179-186.
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