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JTP-117968

Chemical Structure : JTP-117968

CAS No.: 2250132-99-9

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JTP-117968 (JTP117968)

Catalog No.: PC-61852Not For Human Use, Lab Use Only.

JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM.
    JTP-117968 shows highly selective and GR binding affinity, has neither agonist nor antagonist activity against MT receptors.
    JTP-117968 exhibits improved transrepression/transactivation dissociation not only in in vitro assays, but also in in vivo mice experiments.

    Physicochemical Properties

    M.Wt 520.596
    Formula C31H31F3N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4b'S,7'R,8a'S)-4b'-benzyl-7'-hydroxy-N-(2-methylpyridin-3-yl)-7'-(trifluoromethyl)-4b',6',7',8',8a',10'-hexahydro-5'H-spiro[cyclopropane-1,9'-phenanthrene]-2'-carboxamide

    References

    1. Kurimoto T, et al. Eur J Pharmacol. 2017 May 15;803:179-186.

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