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JTT-553 benzosulfonate

Chemical Structure : JTT-553 benzosulfonate

CAS No.:

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JTT-553 benzosulfonate (JTT553)

Catalog No.: PC-62952Not For Human Use, Lab Use Only.

JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM); suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats; also reduces daily food intake and body weight gain in diet-induced obesity rats.

Obesity

Phase 1 Discontinued

Physicochemical Properties

M.Wt 646.682
Formula C31H33F3N4O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

trans-5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic acid monobenzenesulfonate

References

1. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9.

2. Tomimoto D, et al. J Pharmacol Sci. 2015 Sep;129(1):51-8.

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