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JWG-071

Chemical Structure : JWG-071

CAS No.: 2250323-50-1

JWG-071 (JWG071)

Catalog No.: PC-72141Not For Human Use, Lab Use Only.

JWG-071 is a selective Erk5 inhibitor (IC50<20 nM) with reduced Brd4/BET inhibitory activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JWG-071 is a selective ERK5 inhibitor (IC50<20 nM) with reduced Brd4/BET inhibitory activity.
JWG-071 does not suppress the Brd4 target gene c-Myc, unlike XMD8-85.
JWG-071 inhibits Erk5-dependent c-Myc phosphorylation and degradation, specific Erk5 inhibition drives Dnmt3b expression.

Physicochemical Properties

M.Wt 612.779
Formula C34H44N8O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

11-(sec-Butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

References

1. Ignazia Tusa, et al. Oncogene. 2018 May;37(19):2601-2614.

2. Charles A C Williams, et al. Cell Rep. 2016 Aug 16;16(7):1820-8.

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