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JYFY-001

Chemical Structure : JYFY-001

CAS No.: 2756734-42-4

JYFY-001 (JYFY001)

Catalog No.: PC-21438Not For Human Use, Lab Use Only.

JYFY-001 is a small molecule copper chelator with moderate selectivity for targeting copper, potently inhibits cancer proliferation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JYFY-001 is a small molecule copper chelator with moderate selectivity for targeting copper, potently inhibits cancer proliferation.
JYFY-001 displays weak chelating ability with Na+, K+, Ca2+, Zn2+, Mg2+, or Fe2+
JYFY-001 drastically inhibits the proliferation of two CRC cell lines SW620 and HCT116 with IC50  of  5.95 and 10.41 uM, respectively.
JYFY-001 inhibits glucose metabolism and tumorsphere formation CRC cells.
JYFY-001 (10, 20, and 50 mg/kg) inhibits tumor growth in CRC-transplanted tumor model, increases lymphocyte infiltration in transplanted tumor tissue of CRC.
JYFY-001 plays a synergistic role on PD-1 inhibitor in antitumor activity by increasing the infiltration of lymphocytes in tumor tissue.

Physicochemical Properties

M.Wt 269.32
Formula C14H11N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(pyridin-3-yl)thieno[3,2-c]pyridin-4-yl)acetamide

References

1. Xiaolong Shi, et al. Drug Dev Res. 2023 Apr;84(2):312-325.

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