Chemical Structure : JYFY-001
CAS No.:
2756734-42-4
JYFY-001
(JYFY001)
Catalog No.: PC-21438Not For Human Use, Lab Use Only.
JYFY-001 is a small molecule copper chelator with moderate selectivity for targeting copper, potently inhibits cancer proliferation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JYFY-001 is a small molecule copper chelator with moderate selectivity for targeting copper, potently inhibits cancer proliferation.
JYFY-001 displays weak chelating ability with Na+, K+, Ca2+, Zn2+, Mg2+, or Fe2+
JYFY-001 drastically inhibits the proliferation of two CRC cell lines SW620 and HCT116 with IC50 of 5.95 and 10.41 uM, respectively.
JYFY-001 inhibits glucose metabolism and tumorsphere formation CRC cells.
JYFY-001 (10, 20, and 50 mg/kg) inhibits tumor growth in CRC-transplanted tumor model, increases lymphocyte infiltration in transplanted tumor tissue of CRC.
JYFY-001 plays a synergistic role on PD-1 inhibitor in antitumor activity by increasing the infiltration of lymphocytes in tumor tissue.
Physicochemical Properties
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M.Wt
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269.32
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Formula
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C14H11N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(pyridin-3-yl)thieno[3,2-c]pyridin-4-yl)acetamide
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References
1. Xiaolong Shi, et al. Drug Dev Res. 2023 Apr;84(2):312-325.
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