JYQ-88 | PARK7 (DJ-1) inhibitor | Probechem Biochemicals

Chemical Structure : JYQ-88

JYQ-88 (JYQ88)

Catalog No.: PC-49621Not For Human Use, Lab Use Only.

JYQ-88 is a potent, selective and covalent PARK7 inhibitor with IC50 of 0.13 uM in DiFMUAc assays, 100-fold selectivity over UCHL1 (PARK5, IC50=11.1 uM), covalently modifies the active site Cys106.

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Biological Activity

JYQ-88 is a potent, selective and covalent PARK7 (DJ-1) inhibitor with IC50 of 0.13 uM in DiFMUAc assays, 100-fold selectivity over UCHL1 (PARK5, IC50=11.1 uM), covalently modifies the active site Cys106.

Physicochemical Properties

M.Wt	360.40
Formula	C14H16N8O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(5-(2-Azidoacetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-1-cyanopyrrolidine-3carboxamide

References

1. Yuqing Jia, et al. J Med Chem. 2022 Oct 13;65(19):13288-13304.

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JYQ-88 (JYQ88)

Biological Activity

Physicochemical Properties

References

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