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JZL184

Chemical Structure : JZL184

CAS No.: 1101854-58-3

JZL184 (JZL 184)

Catalog No.: PC-20486Not For Human Use, Lab Use Only.

JZL184 (JZL 184) is a potent, selective and irreversible MAGL inhibitor, blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes with IC50 of 8 nM, >300-fold selectivity for MAGL over FAAH.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JZL184 (JZL 184) is a potent, selective and irreversible MAGL inhibitor, blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes with IC50 of 8 nM, >300-fold selectivity for MAGL over FAAH.
JZL184 increases 2-AG but not AEA concentrations in mouse brain.
JZL184-treated mice exhibited a broad array of CB1-dependent behavioral effects, including analgesia, hypothermia and hypomotility.
JZL184 attenuated mechanical and cold allodynia via a CB(1), but not a CB(2), receptor mechanism of action.
JZL184 prolongs depolarization-induced suppression of excitation (DSE) in Purkinje neurons in cerebellar slices and DSI in CA1 pyramidal neurons in hippocampal slices.

Physicochemical Properties

M.Wt 520.49
Formula C27H24N2O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate

References

1. Long JZ, et al. Nat Chem Biol. 2009 Jan;5(1):37-44.

2. Kinsey SG, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):902-10.

3. Pan B, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7.

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