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JZP-430

Chemical Structure : JZP-430

CAS No.: 1672691-74-5

JZP-430 (JZP430)

Catalog No.: PC-20129Not For Human Use, Lab Use Only.

JZP-430 (JZP430) is potent, selective and irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with IC50 of 44 nM (hABHD6), 230-fold selectivity over FAAH and lysosomal acid lipase (LAL).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JZP-430 (JZP430) is potent, selective and irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with IC50 of 44 nM (hABHD6), 230-fold selectivity over FAAH and lysosomal acid lipase (LAL).
JZP-430 is highly selective for ABHD6 over the other detectable brain serine hydrolases, including FAAH, MAGL and ABHD12.

Physicochemical Properties

M.Wt 354.47
Formula C16H26N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate

References

1. Jayendra Z Patel, et al. ChemMedChem. 2015 Feb;10(2):253-65.

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