Jaspamycin | TbPKA inhibitor, MTA3 inhibitor

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Chemical Structure : Jaspamycin

Jaspamycin (7-CN-7-C-Ino)

Catalog No.: PC-23310Not For Human Use, Lab Use Only.

Jaspamycin (7-CN-7-C-Ino) is a potent activator of Trypanosoma brucei PKA (TbPKA), binding to the R site (PKAR) with EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei, also inhibits hepatocellular carcinoma progression via trageting metastasis-associated protein 3 (MTA3).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	292.25
Formula	C12H12N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,7-Dihydro-4-oxo-7-β-D-ribofuranosyl-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

References

1. Sabine Bachmaier, et al. Nat Commun. 2019 Mar 29;10(1):1421.

2. Liu Y, et al. Sci Rep. 2024 Oct 25;14(1):25294.

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Jaspamycin (7-CN-7-C-Ino)

Biological Activity

Physicochemical Properties

References

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