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Jervine

Chemical Structure : Jervine

CAS No.: 469-59-0

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Jervine (11-Ketocyclopamine)

Catalog No.: PC-26424Not For Human Use, Lab Use Only.

Jervine is a steroid alkaloid Smoothened receptor (Smo) antagonist, inhibits Hh signaling pathway with IC50 of 500-700 nM, also is a dual-targeting kinase inhibitor of AURKB and CDK1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Jervine is a steroid alkaloid Smoothened receptor (Smo) antagonist, inhibits Hh signaling pathway with IC50 of 500-700 nM, also is a dual-targeting kinase inhibitor of AURKB and CDK1.

Physicochemical Properties

M.Wt 425.61
Formula C27H39NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3-Hydroxy-3',6',10,11b-tetramethyl-1,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11a,11b-hexadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-11(2H)-one

References

1. Wilson CW, et al. PLoS One. 2009;4(4):e5182.

2. Sulaimani MN, et al. Front Pharmacol. 2025 Nov 21;16:1662556.

3. Williams JA, et al. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.

4. Cooper M K, et al. Science. 1998;280:1603–1607.

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