Chemical Structure : Jun12682
CAS No.:
3055042-10-6
Jun12682
Catalog No.: PC-23384Not For Human Use, Lab Use Only.
Jun12682 is a potent SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki/IC50 values of 37.7/106.8 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Jun12682 is a potent SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki/IC50 values of 37.7/106.8 nM.
Jun12682 inhibits the deubiquitinating and deISGylating activities of PLpro, which are crucial for antagonizing the host's innate immune response upon viral infection.
Jun12682 exhibits potent antiviral activity against SARS-CoV-2 and its variants, including nirmatrelvir-resistant mutants, in Caco-2 cells (EC50: 0.44–2.02 μmol/L).
Jun12682 oral administration significantly improved survival rates and alleviated both lung virus loads and histopathological lesions in a lethal SARS-CoV-2 mouse model.
Physicochemical Properties
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M.Wt
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500.65
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Formula
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C29H36N6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-5-(2-(dimethylamino)ethoxy)-N-(1-(3-(1-ethyl-1H-pyrazol-3-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenyl)ethyl)-2-methylbenzamide
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References
1. Mianling Yang, et al. Acta Pharm Sin B. 2024 Sep;14(9):4189-4192.
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