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KAD-039

Chemical Structure : KAD-039

CAS No.:

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KAD-039 (KAD039)

Catalog No.: PC-27979Not For Human Use, Lab Use Only.

KAD-039 is a 2', 3'-diisobutyrate-5'-ProTide prodrug with potent antiviral activity across flaviviruses, filoviruses and coronaviruses with EC50 values of 1-10 uM aginst ainst DENV and EBOV, potentially functioning through viral methyltransferase inhibition.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KAD-039 is a 2', 3'-diisobutyrate-5'-ProTide prodrug with potent antiviral activity across flaviviruses, filoviruses and coronaviruses with EC50 values of 1-10 uM aginst ainst DENV and EBOV, potentially functioning through viral methyltransferase inhibition.

Physicochemical Properties

M.Wt 773.74
Formula C33H44N9O11P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3S,4R,5R)-5-(4-(2-amino-4-methoxypyrimidin-5-yl)-1H-imidazol-1-yl)-2-azido-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)

References

1. Kyle A Davis, et al. ChemMedChem. 2026 Sep 14;21(17):e70435.

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