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KAN0438757

Chemical Structure : KAN0438757

CAS No.: 1451255-59-6

KAN0438757 (KAN 0438757, KAN-0438757)

Catalog No.: PC-35684Not For Human Use, Lab Use Only.

KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KAN0438757 (KAN-0438757) is a potent, selective PFKFB3 inhibitor, the ester prodrug of KAN0438241 with enhanced cell permeability.
KAN0438757 impairs recruitment of ribonucleotide reductase M2 and deoxynucleotide incorporation upon DNA repair, and reduces dNTP levels.
KAN0438757 selectively inhibits proliferation of transformed cells while sparing nontransformed cells.
KAN0438757 demonstrates significant suppression of intracellular F-2,6-P2 levels with sub µM IC50 values in cell lines representing pancreatic, gastric, and colon cancer (IC50=0.24 uM in Mia Paca-2 cells).

Physicochemical Properties

M.Wt 447.433
Formula C21H18FNO7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-hydroxyethyl 4-((5'-fluoro-2'-hydroxy-[1,1'-biphenyl])-3-sulfonamido)-2-hydroxybenzoate

References

1. Gustafsson NMS, et al. Nat Commun. 2018 Sep 24;9(1):3872.

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