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KB-151

Chemical Structure : KB-151

CAS No.: 907986-18-9

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KB-151 (KB151)

Catalog No.: PC-23439Not For Human Use, Lab Use Only.

KB-151 is a small molecule phagocytosis inhibitor with IC50 of 2.7 uM in human PBMCs, shows no significant toxicity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KB-151 is a small molecule phagocytosis inhibitor with IC50 of 2.7 uM in human PBMCs, shows no significant toxicity.
KB-151 is also able to inhibit phagocytosis in a murine system, albeit at a higher IC50 values.
KB-151 shows efficacy to ameliorate experimental ITP and AIHA, reverses ITP and/or AIHA, or cooperate with IVIG to increase efficacy.

Physicochemical Properties

M.Wt 457.29
Formula C19H17BrN6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 4-(4-bromo-1-ethyl-1H-pyrazole-3-carboxamido)-5-cyano-1-phenyl-1H-pyrazole-3-carboxylate

References

1. Loriamini M, et al. Small molecule drugs that inhibit phagocytosis. Molecules. 2023; 28(2): 757.

2. Loriamini M, et al. Transfusion. 2024 Nov 7. doi: 10.1111/trf.18060.

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