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KBU2046

Chemical Structure : KBU2046

CAS No.: 1143863-69-7

KBU2046 (KBU 2046;KBU-2046)

Catalog No.: PC-35293Not For Human Use, Lab Use Only.

KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.

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Biological Activity

KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.
KBU2046 selectively disrupts heterocomplex function and inhibits cancer cell motility, only binds to HSP90β and CDC37 when both proteins are present, does not bind to either protein alone.
KBU2046 decreases phosphorylation of HSP90β, inhibits cancer metastasis and prolongs life in vivo.
KBU2046-mediated changes in the signature of client proteins bound to the HSP90β/CDC37 heterocomplex mediate effects upon cell motility.

Physicochemical Properties

M.Wt 242.249
Formula C15H11FO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(4-fluorophenyl)chroman-4-one

References

1. Xu L, et al. Nat Commun. 2018 Jun 22;9(1):2454.

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