KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes.
KBU2046 selectively disrupts heterocomplex function and inhibits cancer cell motility, only binds to HSP90β and CDC37 when both proteins are present, does not bind to either protein alone.
KBU2046 decreases phosphorylation of HSP90β, inhibits cancer metastasis and prolongs life in vivo.
KBU2046-mediated changes in the signature of client proteins bound to the HSP90β/CDC37 heterocomplex mediate effects upon cell motility.
Physicochemical Properties
M.Wt
242.249
Formula
C15H11FO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3-(4-fluorophenyl)chroman-4-one
References
1. Xu L, et al. Nat Commun. 2018 Jun 22;9(1):2454.
