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KC289

Chemical Structure : KC289

CAS No.:

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KC289 (KC 289)

Catalog No.: PC-49556Not For Human Use, Lab Use Only.

KC289 is a specific small-molecule agonist of PIEZO1 channel and Yoda1 analogue with EC50 of 150 nM in in calcium assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KC289 is a specific small-molecule agonist of PIEZO1 channel and Yoda1 analogue with EC50 of 150 nM in calcium assays.
    KC289 is selectivity for PIEZO1 over other membrane proteins and the physico-chemical properties, and is more suited to physiological conditions than those of Yoda1.
    KC289 shows improved reliability, efficacy and potency compared to Yoda1 in functional assays.
    KC289 may have therapeutic potential, for example in diseases linked genetically to PIEZO1 such as lymphatic dysplasia.

    Physicochemical Properties

    M.Wt 435.378
    Formula C16H9Cl2KN2O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Potassium 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate

    References

    1. Gregory Parsonage, et al. Br J Pharmacol. 2022 Dec 1. doi: 10.1111/bph.15996.

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