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KCB-F06

Chemical Structure : KCB-F06

CAS No.: 474089-46-8

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KCB-F06

Catalog No.: PC-22794Not For Human Use, Lab Use Only.

KCB-F06 is a small molecule Keap1-Nrf2 PPI inhibitor, inhibits RANKL-induced osteoclastogenesis in vitro and blocks OVX-mouse bone loss in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KCB-F06 is a small molecule Keap1-Nrf2 PPI inhibitor, inhibits RANKL-induced osteoclastogenesis in vitro and blocks OVX-mouse bone loss in vivo.
KCB-F06 enhances the expression of Nrf2 and subsequent inhibition of osteoclastogenesis.
KCB-F06 can block osteoclastogenesis by activating Nrf2-mediated oxidative stress response.
KCB-F06 suppresses the RANKL-induced phosphorylation of I-κB and p65 NF-kB in pre-osteoclasts.
KCB-F06 inhibits osteoclast-specific gene expression during RANKL-induced osteoclastogenesis.  

Physicochemical Properties

M.Wt 454.60
Formula C24H26N2O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-methyl-4-(phenylsulfanylmethyl)phenyl]-2-(N-methylsulfonylanilino)propanamide

References

1. Chen Z, et al. Antioxidants (Basel). 2024 Jul 15;13(7):850.

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