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KDM2A/7A inhibitor 1

Chemical Structure : KDM2A/7A inhibitor 1

CAS No.: 2169272-46-0

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KDM2A/7A inhibitor 1 (KDM2A/7A-IN-1)

Catalog No.: PC-61815Not For Human Use, Lab Use Only.

KDM2A/7A inhibitor 1 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KDM2A/7A inhibitor 1 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM, respectively.
    KDM2A/7A inhibitor 1 displays >75 fold selectivity towards KDM2A/7A versus other JmjC lysine demethylase.
    KDM2A/7A inhibitor 1 shows cytotoxicity towards HeLa and HAP1 cells with EC50 of 22 uM and 7.1 uM respectively.

    Physicochemical Properties

    M.Wt 506.694
    Formula C33H38N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S,3S)-1-acetyl-3-phenyl-2-(5-(7-(pyrrolidin-1-yl)heptyl)pyridin-3-yl)indoline-3-carbonitrile

    References

    1. Gerken P, et al. Angew Chem Int Ed Engl. 2017 Oct 4. doi: 10.1002/anie.201706788.

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