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KDM4/5 inhibitor 19a

Chemical Structure : KDM4/5 inhibitor 19a

CAS No.: 2369607-62-3

KDM4/5 inhibitor 19a

Catalog No.: PC-22360Not For Human Use, Lab Use Only.

KDM4/5 inhibitor 19a is a potent, cell penetrant, dual KDM4/5-subfamily inhibitor with Ki values of 4 nM/7 nM for KDM4A/KDM5B, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KDM4/5 inhibitor 19a is a potent, cell penetrant, dual KDM4/5-subfamily inhibitor with Ki values of 4 nM/7 nM for KDM4A/KDM5B, respectively.
KDM4/5 inhibitor 19a potently inhibits KDM4A, KDM4B, KDM5B and KDM5C with IC50 of 0.1, 0.043, 0.038 and 0.123 uM, respectively.

Physicochemical Properties

M.Wt 426.52
Formula C25H26N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

8-(4-(2-(2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl)ethyl)-1H-pyrazol-1-yl)pyrido[3,4-d]pyrimidin-4(3H)-one

References

1. Yann-Vaï Le Bihan, et al. Eur J Med Chem. 2019 Sep 1:177:316-337.

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