KDM4/5 inhibitor 19a

Chemical Structure : KDM4/5 inhibitor 19a

Catalog No.: PC-22360Not For Human Use, Lab Use Only.

KDM4/5 inhibitor 19a is a potent, cell penetrant, dual KDM4/5-subfamily inhibitor with Ki values of 4 nM/7 nM for KDM4A/KDM5B, respectively.

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Biological Activity

KDM4/5 inhibitor 19a is a potent, cell penetrant, dual KDM4/5-subfamily inhibitor with Ki values of 4 nM/7 nM for KDM4A/KDM5B, respectively.
KDM4/5 inhibitor 19a potently inhibits KDM4A, KDM4B, KDM5B and KDM5C with IC50 of 0.1, 0.043, 0.038 and 0.123 uM, respectively.

Physicochemical Properties

M.Wt	426.52
Formula	C25H26N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(4-(2-(2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl)ethyl)-1H-pyrazol-1-yl)pyrido[3,4-d]pyrimidin-4(3H)-one

References

1. Yann-Vaï Le Bihan, et al. Eur J Med Chem. 2019 Sep 1:177:316-337.

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