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KDM5-C49

Chemical Structure : KDM5-C49

CAS No.: 1596348-16-1

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KDM5-C49 (KDM5 inhibitor C49)

Catalog No.: PC-62294Not For Human Use, Lab Use Only.

KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively.
KDM5-C49 displays 25-100-fold selectivity over KDM6B, 2-30-fold selectivity over KDM4 family, but with less cell-permeablity.

Physicochemical Properties

M.Wt 308.382
Formula C15H24N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid

References

1. Johansson C, et. Nat Chem Biol. 2016 Jul;12(7):539-45.

2. Horton JR, et al. Cell Chem Biol. 2016 Jul 21;23(7):769-81.

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