KDRLKZ-1

Chemical Structure : KDRLKZ-1

Catalog No.: PC-22816Not For Human Use, Lab Use Only.

KDRLKZ-1 is a small-molecule ligand targeting the E3 ligase KLHDC2 with SPR Kd of 0.36 uM, dosplaces the SelK peptide with IC50 of 0.21 uM as measured by alphaLISA.

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Biological Activity

KDRLKZ-1 is a small-molecule ligand targeting the E3 ligase KLHDC2 with SPR Kd of 0.36 uM, dosplaces the SelK peptide with IC50 of 0.21 uM as measured by alphaLISA.
KDRLKZ-1 binds to KLHDC2 in its substrate-binding pocket and can displace its natural substrate.

Physicochemical Properties

M.Wt	459.50
Formula	C23H29N3O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(3-(sec-butyl)-7-((2-methoxyethoxy)carbonyl)-2-oxo-5,6,7,8-tetrahydro-1,7-naphthyridin-1(2H)-yl)-2-oxopyridin-1(2H)-yl)acetic acid

References

1. Hickey CM, et al. Nat Struct Mol Biol. 2024 Feb;31(2):311-322.

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KDRLKZ-1

Biological Activity

Physicochemical Properties

References

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