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KDU691

Chemical Structure : KDU691

CAS No.: 1513879-19-0

KDU691 (KDU-691)

Catalog No.: PC-61696Not For Human Use, Lab Use Only.

KDU691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KDU691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K).
KDU691 shows IC50 of 58 nM, 36 nM and 196 nM against P. falciparum (Pf, boold stages), P. yoelii (Py, schizont) and P. cynomolgi (Pc, hypnozoites) respectively.
KDU691 shows fully protective effect against P. cynomolgi sporozoites in animal models.

Physicochemical Properties

M.Wt 419.864
Formula C22H18ClN5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-Chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]imidazo[1,2-a]pyrazine-6-carboxamide

References

1. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.

2. Zeeman AM, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.

3. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.

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