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Chemical Structure : KDU691
CAS No.: 1513879-19-0
Catalog No.: PC-61696Not For Human Use, Lab Use Only.
KDU691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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KDU691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K).
KDU691 shows IC50 of 58 nM, 36 nM and 196 nM against P. falciparum (Pf, boold stages), P. yoelii (Py, schizont) and P. cynomolgi (Pc, hypnozoites) respectively.
KDU691 shows fully protective effect against P. cynomolgi sporozoites in animal models.
| M.Wt | 419.864 | |
| Formula | C22H18ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-Chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]imidazo[1,2-a]pyrazine-6-carboxamide |
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1. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.
2. Zeeman AM, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.
3. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.
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