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KF26777

Chemical Structure : KF26777

CAS No.: 206129-88-6

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KF26777 (KF-26777)

Catalog No.: PC-20639Not For Human Use, Lab Use Only.

KF-26777 (KF26777) is a potent and selective adenosine A3 receptor antagonist with Ki of 0.2 nM (human A3 receptor).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KF-26777 (KF26777) is a potent and selective adenosine A3 receptor antagonist with Ki of 0.2 nM (human A3 receptor).
    KF-26777 displays 9000-, 2350- and 3100-fold selectivity vs. human adenosine A(1), A(2A) and A(2B) receptors, respectively.
    KF26777 inhibits the binding of [35S]GTPgammaS stimulated by 1 microM 2-Cl-IB-MECA in competitive binding assays (IC50=250 nM).
    KF26777 antagonizes [Ca(2+)](i) mobilization induced by Cl-IB-MECA with K(B) value of 0.42 nM.

    Physicochemical Properties

    M.Wt 374.24
    Formula C16H16BrN5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-bromophenyl)-4-propyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one

    References

    1. Saki M, et al. Eur J Pharmacol. 2002 May 31;444(3):133-41.

    2. Yamano K, et al. Biochem Pharmacol. 2005 Nov 15;70(10):1487-96.

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