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KH-176

Chemical Structure : KH-176

CAS No.: 1541170-75-5

KH-176 (Sonlicromanol;KH176)

Catalog No.: PC-36101Not For Human Use, Lab Use Only.

KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system.

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    Biological Activity

    KH-176 (KH176, Sonlicromanol) is a smal molecule ROS-redox modulator, effectively reduces increased cellular ROS levels and protects OXPHOS deficient primary cells against redox perturbation by targeting the Thioredoxin/Peroxiredoxin system.
    KH-176 significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice.
    KH-176 shows therapeutic effects in mammalian model of Leigh Disease.

    Physicochemical Properties

    M.Wt 332.444
    Formula C19H28N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydro-2H-1-benzopyran-2-carboxamide

    References

    1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733.

    2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163.

    3. Beyrath J, et al. Sci Rep. 2018 Apr 26;8(1):6577.

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