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KH-CB19

Chemical Structure : KH-CB19

CAS No.: 1354037-26-5

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KH-CB19 (KH-CB-19)

Catalog No.: PC-43237Not For Human Use, Lab Use Only.

KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform.
    KH-CB19 effectively suppresses phosphorylation of SR (serine/arginine) proteins SRp75 and SRp55 in cells.
    KH-CB19 significantly reduces the basal expression of flTF as well as asHTF, also lowers TNF-α-induced expression of both TF mRNA splice variants to baseline in HMEC-1 cells.

    Physicochemical Properties

    M.Wt 338.1886
    Formula C15H13Cl2N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1H-Indole-2-carboxylic acid, 3-[(1E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-, ethyl ester

    References

    1. Fedorov O, et al. Chem Biol. 2011 Jan 28;18(1):67-76.

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