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KH 176

Chemical Structure : KH 176

CAS No.: 2162149-24-6

KH 176 (KH176, Sonlicromanol hydrochloride)

Catalog No.: PC-62601Not For Human Use, Lab Use Only.

KH176 (Sonlicromanol) is a chemical entity derivative of Trolox and small molecule ROS-redox modulator, shows potential treatment for mitochondrial disorders.

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    Biological Activity

    KH176 (Sonlicromanol) is a chemical entity derivative of Trolox and small molecule ROS-redox modulator, shows potential treatment for mitochondrial disorders.
    KH176 retains brain microstructural coherence in the external capsule in Ndufs4 -/- mice and normalizes the increased lipid peroxidation in this area and the cerebral cortex.
    KH176 significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice.

    Physicochemical Properties

    M.Wt 368.902
    Formula C19H29ClN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-6-hydroxy-2,5,7,8-tetramethyl-N-((R)-piperidin-3-yl)chroman-2-carboxamide hydrochloride

    References

    1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733.

    2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163.

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