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Chemical Structure : KHK-IN-8 hydrochloride
CAS No.: 1303470-48-5
Catalog No.: PC-43253Not For Human Use, Lab Use Only.
KHK-IN-8 hydrochloride is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK, also shows potent cellular KHK inhibition with IC50 of <500 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $138 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $498 | In stock | |
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| 100 mg | Get quote |
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KHK-IN-8 hydrochloride is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK, also shows potent cellular KHK inhibition with IC50 of <500 nM.
| M.Wt | 459.0107 | |
| Formula | C21H27ClN8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrimido[5,4-d]pyrimidine-4,8-diamine, N8-(cyclopropylmethyl)-N4-[2-(methylthio)phenyl]-2-(1-piperazinyl)-, hydrochloride (1:1) |
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1. Maryanoff BE, et al. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.
2. Maryanoff BE, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9.
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