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KI-MS2-008

Chemical Structure : KI-MS2-008

CAS No.: 2125730-80-3

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KI-MS2-008

Catalog No.: PC-20800Not For Human Use, Lab Use Only.

KI-MS2-008 is a small molecule Max binder that modulate Myc-driven transcription in cells (IC50=1.28 uM) and inhibit viable cell levels in a Myc-dependent manner.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KI-MS2-008 is a small molecule Max binder that modulate Myc-driven transcription in cells (IC50=1.28 uM) and inhibit viable cell levels in a Myc-dependent manner.
    KI-MS2-008 induces Max/Max homodimerization.
    KI-MS2-008 (10 uM) decreases Myc protein levels and affects the global Myc transcriptional program in ST486 cells.
    KI-MS2-008 also decreases viable cancer cell growth in a Myc-dependent manner and suppresses tumor growth in vivo.

    Physicochemical Properties

    M.Wt 536.65
    Formula C32H28N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3aS,10bS)-3a-benzyl-2-phenyl-5-(2-(phenylsulfonyl)ethyl)-3a,5,6,10b-tetrahydro-4H-benzo[c]oxazolo[5,4-e]azepin-4-one

    References

    1. Struntz NB, et al. Cell Chem Biol. 2019 May 16;26(5):711-723.e14.

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