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KIF18A inhibitor compound 3

Chemical Structure : KIF18A inhibitor compound 3

CAS No.: 2446613-56-3

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KIF18A inhibitor compound 3

Catalog No.: PC-22245Not For Human Use, Lab Use Only.

KIF18A inhibitor compound 3 is a potent, selective mitotic kinesin KIF18A inhibitor of IC50 of 8.2 nM, inhibits KIF18A's microtubule-stimulated ATPase activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KIF18A inhibitor compound 3 is a potent, selective mitotic kinesin KIF18A inhibitor of IC50 of 8.2 nM, inhibits KIF18A's microtubule-stimulated ATPase activity.

Physicochemical Properties

M.Wt 565.64
Formula C25H33F2N7O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-6-((2-hydroxyethyl)sulfonamido)-4-(6-azaspiro[2.5]octan-6-yl)nicotinamide

References

1. Schutt KL, et al. Front Mol Biosci. 2024 Feb 12;11:1328077.

2. Tamayo N. A., et al. J. Med. Chem. 65, 4972–4990.

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