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Chemical Structure : KIRA-7
Catalog No.: PC-36003Not For Human Use, Lab Use Only.
KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity.
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KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity.
KIRA-7 reverses bleomycin-induced fibrosis when given 2 weeks after bleomycin exposure in vivo.
| M.Wt | 466.52 | |
| Formula | C27H23FN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thamsen M, et al. PLoS One. 2019 Jan 9;14(1):e0209824.
2. Feldman HC, et al. ACS Chem Biol. 2016 Aug 19;11(8):2195-205.
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