KIRA-7 |CAS:1937235-76-1 Probechem Biochemicals

You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-IRE1-KIRA-7

Chemical Structure : KIRA-7

KIRA-7 (KIRA7)

Catalog No.: PC-36003Not For Human Use, Lab Use Only.

KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity.

Packing	Price	Stock	Quantity
10 mg		Get quote
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity.
KIRA-7 reverses bleomycin-induced fibrosis when given 2 weeks after bleomycin exposure in vivo.

Physicochemical Properties

M.Wt	466.52
Formula	C27H23FN6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(8-amino-3-(1-methylcyclopropyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-fluorophenyl)urea

References

1. Thamsen M, et al. PLoS One. 2019 Jan 9;14(1):e0209824.

2. Feldman HC, et al. ACS Chem Biol. 2016 Aug 19;11(8):2195-205.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

KIRA-7 (KIRA7)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.