KIRA-7 |CAS:1937235-76-1 Probechem Biochemicals

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Chemical Structure : KIRA-7

KIRA-7 (KIRA7)

Catalog No.: PC-36003Not For Human Use, Lab Use Only.

KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity.
KIRA-7 reverses bleomycin-induced fibrosis when given 2 weeks after bleomycin exposure in vivo.

Physicochemical Properties

M.Wt	466.52
Formula	C27H23FN6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(8-amino-3-(1-methylcyclopropyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-fluorophenyl)urea

References

1. Thamsen M, et al. PLoS One. 2019 Jan 9;14(1):e0209824.

2. Feldman HC, et al. ACS Chem Biol. 2016 Aug 19;11(8):2195-205.

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KIRA-7 (KIRA7)

Biological Activity

Physicochemical Properties

References

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