KJ-Pyr-9 | Myc inhibitor | Probechem Biochemicals

Chemical Structure : KJ-Pyr-9

CAS No.: 581073-80-5

KJ-Pyr-9 (KJ Pyr 9)

Catalog No.: PC-45695Not For Human Use, Lab Use Only.

KJ-Pyr-9 is a specific small-molecule inhibitor of MYC, inhibits MYC-MAX interaction, directly binds to MYC (Kd=6.5 nM) as well as to the MYC-MAX heterodimer (Kd=13.4 nM), interferes with its transcriptional and oncogenic activities.

Packing	Price	Stock
5 mg	$48	In stock
10 mg	$78	In stock
25 mg	$128	In stock
50 mg	$198	In stock
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Biological Activity

KJ-Pyr-9 is a specific small-molecule inhibitor of MYC, inhibits MYC-MAX interaction, directly binds to MYC (Kd=6.5 nM) as well as to the MYC-MAX heterodimer (Kd=13.4 nM), interferes with its transcriptional and oncogenic activities.

KJ-Pyr-9 displays significantly higher affinity for MYC–MAX over MAX–MAX dimers.

KJ-Pyr-9 strongly inhibits oncogenic activity of N-MYC and ATG-MYC, but not v-Src, v-Jun, and the H1047R mutant of phosphatidylinositol 3-kinase (PI3K).

KJ-Pyr-9 inhibits the proliferation of Burkitt lymphoma P493-6 cells with constitutively high expression of c-MYC with IC50 of 1-2.5 uM.

KJ-Pyr-9 (10 mg/kg, i.p. injection for 31 d) inhibits tumor growth of a xenograft of MDA-MB-231 cells, with no effect on the body weight of the animals, increases MYC suppression target NDRG1.

Physicochemical Properties

M.Wt	385.3722
Formula	C22H15N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-

References

1. Hart JR, et al. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61.

2. Raffeiner P, et al. Oncotarget. 2014 Oct 15;5(19):8869-78.

KJ-Pyr-9 (KJ Pyr 9)

Biological Activity

Physicochemical Properties

References

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