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KM04794

Chemical Structure : KM04794

CAS No.: 882287-24-3

KM04794 (KM 04794, KM-04794)

Catalog No.: PC-72838Not For Human Use, Lab Use Only.

KM04794 (KM-04794) is a chemical chaperone-like small molecule modulator of endoplasmic reticulum (ER) proteostasis and alleviates ER stress, inhibits UPR signaling with IC50 of 10 uM.

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    Biological Activity

    KM04794 (KM-04794) is a chemical chaperone-like small molecule modulator of endoplasmic reticulum (ER) proteostasis and alleviates ER stress, inhibits UPR signaling with IC50 of 10 uM.
    KM04794 accumulates in the ER and directly interacts amd binds to with the ER molecular chaperone BiP, KM04794 inhibits the aggregation of GAPDH in cooperation with BiP.
    KM04794 suppresses Tm-induced phosphorylation of IRE1 and PERK and induction of XBP1 and
    ATF4 in the MIN6m9 pancreatic β cell line.
    KM04794 suppresses UPR activation induced by brefeldin A.
    KM04794 alleviates ER protein aggregation and ER stress-induced cell death, and mutant insulin-induced ER stress.
    KM04794 increases intracellular and secreted insulin levels in pancreatic β cells.

    Physicochemical Properties

    M.Wt 494.913
    Formula C23H18ClF3N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N'-(2-(2-((4-chlorobenzyl)thio)phenoxy)acetyl)-3-(trifluoromethyl)benzohydrazide

    References

    1. Masato Miyake, et al. Cell Chem Biol. 2022 Feb 7;S2451-9456(22)00002-2.

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