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KOTX1

Chemical Structure : KOTX1

CAS No.: 1788963-83-6

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KOTX1 (ALDH1A3 inhibitor KOTX1)

Catalog No.: PC-20212Not For Human Use, Lab Use Only.

KOTX1 is a potent, selective and reversible ALDH1A3 inhibitor with IC50 of 5.14 nM by Aldefluor assay in A375 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KOTX1 is a potent, selective and reversible ALDH1A3 inhibitor with IC50 of 5.14 nM by Aldefluor assay in A375 cells.
    KOTX1 does not inhibit the closely related ALDH1A1 or ALDH2 isoforms.
    KOTX1 (40 mg/kg/day, oral gavage, 1 week) inhibits ALDH1A3 activity and restores β-cell function and maturity in db/db mice.
    KOTX1 IC50 is 10-fold lower in human A375 cells than in diabetic mouse islets.
    KOTX1 (40 mg/kg/day, oral gavage) improved glucose control, increased insulin secretion, and enhanced glucose tolerance in male DIO mice.

    Physicochemical Properties

    M.Wt 313.33
    Formula C17H16FN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-ethyl-N-(7-fluoro-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)isonicotinamide

    References

    1. Jinsook Son, et al. Nat Commun. 2023 Feb 2;14(1):558.

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