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KRAS4b-PDEδ stablizer C19

Chemical Structure : KRAS4b-PDEδ stablizer C19

CAS No.: 2714973-81-4

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KRAS4b-PDEδ stablizer C19

Catalog No.: PC-35765Not For Human Use, Lab Use Only.

KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells。
    KRAS4b-PDEδ stablizer C19  showed high cytotoxicity in the colorectal cancer cell lines HCT116 and LoVo, with a stronger effect in KRAS-dependent LoVo cells.
    KRAS4b-PDEδ stablizer C19  significantly decreased tumor size in a xenograft mouse model and showed lower side effects than 5-FU.

    Physicochemical Properties

    M.Wt 385.285
    Formula C18H22Cl2N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S)-N-(2,5-dichlorophenyl)-2-(((3,4-dimethoxycyclohexa-2,5-dien-1-yl)methyl)amino)propanamide

    References

    1. Cruz-Nova P, et al. BMC Cancer. 2018 Nov 1;18(1):1056.

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