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Chemical Structure : KRAS4b-PDEδ stablizer C19
Catalog No.: PC-35765Not For Human Use, Lab Use Only.
KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells.
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KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells。
KRAS4b-PDEδ stablizer C19 showed high cytotoxicity in the colorectal cancer cell lines HCT116 and LoVo, with a stronger effect in KRAS-dependent LoVo cells.
KRAS4b-PDEδ stablizer C19 significantly decreased tumor size in a xenograft mouse model and showed lower side effects than 5-FU.
| M.Wt | 385.285 | |
| Formula | C18H22Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cruz-Nova P, et al. BMC Cancer. 2018 Nov 1;18(1):1056.
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