KRAS G12C inhibitor 11 |CAS:2158297-63-1 Probechem Biochemicals

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Chemical Structure : KRAS G12C inhibitor 11

KRAS G12C inhibitor 11

Catalog No.: PC-35953Not For Human Use, Lab Use Only.

KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM.
KRAS G12C inhibitor 11 demonstrates super proportional dose ascending oral exposure in mice with 3h target coverage at the 30 mg/kg dose.
KRAS G12C inhibitor 11 shows rapid growth inhibition and durable efficacy even after dosing was stopped, orally active.

Physicochemical Properties

M.Wt	551.695
Formula	C32H37N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((S)-1-acryloyl-4-(2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile

References

1. U.S. Pat. Appl. Publ. (2018), US 20180072723 A1 20180315.

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