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Chemical Structure : KRAS G12C inhibitor 13
Catalog No.: PC-35878Not For Human Use, Lab Use Only.
KRAS G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays.
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KRAS G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays.
KRAS-G12C inhibitor 13 displays no significant activity against non-G12C cell lines with IC50 of >16 uM.
KRAS-G12C inhibitor 13 demonstrates KRAS-G12C target engagement in vivo and antitumor efficacy in the MIA PaCa-2 tumor xenograft models.
| M.Wt | 528.657 | |
| Formula | C30H36N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jay B. Fell, et al. Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00382.
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