KRAS G12V inhibitor Cmpd2

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Chemical Structure : KRAS G12V inhibitor Cmpd2

Catalog No.: PC-35593Not For Human Use, Lab Use Only.

KRAS G12V inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.

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Biological Activity

KRAS G12V inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.
KRAS G12V inhibitor Cmpd2 inhibits cell proliferation in SW1990 cells with EC50 of 2.7 uM.
The potency of Cmpd2 was strongly enhanced when prenylated K-RAS4B is associated with a lipid bilayer.

Physicochemical Properties

M.Wt	446.773
Formula	C21H21BrClN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-bromo-N-((2R,4S)-2-(4-chlorobenzyl)piperidin-4-yl)-1H-indole-3-carboxamide

References

1. Fang Z, et al. Cell Chem Biol. 2018 Aug 14. pii: S2451-9456(18)30261-7.

2. Jansen JM, et al. PLoS One. 2017 Apr 6;12(4):e0174706.

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