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Chemical Structure : KRH-3955
Catalog No.: PC-61294Not For Human Use, Lab Use Only.
KRH-3955 is a potent, selective, orally bioavailable inhibitor of CXCR4 that efficiently inhibits SDF-1α binding to CXCR4 with IC50 of 0.61 nM.
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KRH-3955 is a potent, selective, orally bioavailable inhibitor of CXCR4 that efficiently inhibits SDF-1α binding to CXCR4 with IC50 of 0.61 nM.
KRH-3955 inhibits the replication of both X4 and R5X4 HIV-1 in activated PBMCs with EC50 of 0.3 to 1.0 nM but does not affect R5 HIV-1 replication.
KRH-3955 also inhibits the replication of clinical isolates of X4 HIV-1 (92HT599) and R5X4 HIV-1 (92HT593) (EC50=4.0-4.2 nM) in activated PBMCs.
KRH-3955 exhibits inhibition of Ca2+ signaling through CXCR4, blocks X4 HIV-1 replication in human PBL/SCID mice.
| M.Wt | 929.975 | |
| Formula | C40H63N7O18 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Murakami T, et al. Antimicrob Agents Chemother. 2009 Jul;53(7):2940-8.
2. Iwasaki Y, et al. Cancer Sci. 2009 Apr;100(4):778-81.
3. Nakasone T, et al. Med Microbiol Immunol. 2013 Apr;202(2):175-82.
4. Hikichi Y, et al. J Gen Virol. 2016 Sep;97(9):2427-40.
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