Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-KRIBB11
KRIBB11

Chemical Structure : KRIBB11

CAS No.: 342639-96-7

KRIBB11 (KRIBB-11;KRIBB 11)

Catalog No.: PC-42278Not For Human Use, Lab Use Only.

KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.

Packing Price Stock Quantity
10 mg $78 In stock
25 mg $128 In stock
50 mg $198 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.
KRIBB11 inhibits HSF1 downstream target proteins HSP70 and HSP72 synthesis, induces growth arrest and apoptosis in HCT-116 cells, inhibits HSF1-dependent recruitment of p-TEFb to the hsp70 promoter.
KRIBB11 inhibits tumor growth without body weight loss in mice model.

Physicochemical Properties

M.Wt 284.27338
Formula C13H12N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 27 mg/mL

Chemical Name/SMILES

2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro-

References

1. Yoon YJ, et al. J Biol Chem. 2011 Jan 21;286(3):1737-47.

2. Kang MJ, et al. Biochem Biophys Res Commun. 2017 Oct 21;492(3):304-309.

3. Carpenter RL, et al. Oncotarget. 2017 May 22;8(43):73947-73963.

4. Samarasinghe B, et al. Biochem Pharmacol. 2014 Feb 1;87(3):445-55.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: