KRP-6 | MIF inhibitor | Probechem Biochemicals

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Chemical Structure : KRP-6

KRP-6 (MIF inhibitor KRP-6)

Catalog No.: PC-21293Not For Human Use, Lab Use Only.

KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration.
KRP-6 does not affect MIF enolase activity.
KRP-6 prevents M1 macrophage polarization and reduces ROS production in IFN-γ-treated cells.
KRP-6 improves mitochondrial bioenergetics by ameliorating basal respiration, ATP production, coupling efficiency and maximal respiration in LPS+IFN-γ-treated cells.
KRP-6 also reduces glycolytic flux in M1 macrophages.

Physicochemical Properties

M.Wt	266.30
Formula	C17H14O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	E-3-(2-methoxybenzylidene)chroman-4-one

References

1. Vámos E, et al.Antioxidants (Basel). 2023 Sep 22;12(10):1790.

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KRP-6 (MIF inhibitor KRP-6)

Biological Activity

Physicochemical Properties

References

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