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Chemical Structure : KRP-6
Catalog No.: PC-21293Not For Human Use, Lab Use Only.
KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration.
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KRP-6 is a potent and highly selective macrophage migration inhibitory factor (MIF) ketonase inhibitor with IC50 of 4.31 uM, significantly reduces MIF-induced neutrophil migration.
KRP-6 does not affect MIF enolase activity.
KRP-6 prevents M1 macrophage polarization and reduces ROS production in IFN-γ-treated cells.
KRP-6 improves mitochondrial bioenergetics by ameliorating basal respiration, ATP production, coupling efficiency and maximal respiration in LPS+IFN-γ-treated cells.
KRP-6 also reduces glycolytic flux in M1 macrophages.
| M.Wt | 266.30 | |
| Formula | C17H14O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vámos E, et al.Antioxidants (Basel). 2023 Sep 22;12(10):1790.
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