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KRas-IN-1

Chemical Structure : KRas-IN-1

CAS No.: 84783-01-7

KRas-IN-1

Catalog No.: PC-45517Not For Human Use, Lab Use Only.

A chemical fragment hit that binds to K-Ras (G12D) with affinities of 1.3-2 mM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A chemical fragment hit that binds to K-Ras (G12D) with affinities of 1.3-2 mM; binds to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.

Physicochemical Properties

M.Wt 207.292
Formula C11H13NOS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

Methanethione, (2-hydroxyphenyl)-1-pyrrolidinyl-

References

1. Sun Q, et al. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3.

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