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KS100

Chemical Structure : KS100

CAS No.: 2408477-53-0

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KS100 (ALDH inhibitor KS100, KS 100)

Catalog No.: PC-38166Not For Human Use, Lab Use Only.

ALDH inhibitor KS100 (KS100) is a novel, potent, multi-isoform ALDH inhibitor with IC50 of 207/1410/240 nM for ALDH1A1/ALDH2/ALDH3A1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ALDH inhibitor KS100 (KS100) is a novel, potent, multi-isoform ALDH inhibitor with IC50 of 207/1410/240 nM for ALDH1A1/ALDH2/ALDH3A1, respectively.
    KS100 was mitigated by development of a nanoliposomal formulation, called NanoKS100. NanoKS100 was 5-fold more selective for killing melanoma cells compared with normal human fibroblasts.
    Inhibition by KS100 significantly reduced total cellular ALDH activity to increase reactive oxygen species generation, lipid peroxidation, and accumulation of toxic aldehydes leading to apoptosis and autophagy.

    Physicochemical Properties

    M.Wt 483.178
    Formula C17H13Br2N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-((5,7-dibromo-2,3-dioxoindolin-1-yl)methyl)benzyl carbamimidothioate

    References

    1. Dinavahi SS, et al. Mol Cancer Ther. 2020 Feb;19(2):447-459.

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