Chemical Structure : KS79356
CAS No.:
416885-25-1
KS79356
(KS-79356)
Catalog No.: PC-27922Not For Human Use, Lab Use Only.
KS79356 is a potent small molecule inhibitor of Kynureninase (KYNU) with IC50 of 63.7 nM in cell-free kynureninase activity assays, displaying strong binding affinity (-7.8 kcal/mol), selectively suppresses proliferation of SUM159 (G50=233 nM) and MDA-MB-231 (GI50=450.8 nM) cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KS79356 is a potent small molecule inhibitor of Kynureninase (KYNU) with IC50 of 63.7 nM in cell-free kynureninase activity assays, displaying strong binding affinity (-7.8 kcal/mol), selectively suppresses proliferation of SUM159 (G50=233 nM) and MDA-MB-231 (GI50=450.8 nM) cells.
KS79356 downregulates TNF-α–induced activation of the NFκB–CD44–Akt signal ing axis, leading to reduced proliferation, invasion, and trans-endothelial migration, while inducing both early and late apoptosis in TNBC cells.
KS79356 demonstrates strong antitumor activity in TNBC.
Physicochemical Properties
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M.Wt
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338.32
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Formula
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C17H14N4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N'-(5,7-dimethyl-2-oxoindolin-3-ylidene)-3-nitrobenzohydrazide
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References
1. Alghamdi MA, et al. Med Oncol. 2026 Aug 29;43(10):259.
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