Catalog No.: PC-73318Not For Human Use, Lab Use Only.
KSQ-4279 (RO7623066) is a potent, selective, first-in-class inhibitor of USP1, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2.
KSQ-4279 (RO7623066) is a potent, selective, first-in-class inhibitor of USP1 with Ki of 1.2 nM, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2.
KSQ-4279 has a unique mode of allosteric binding to USP1 and a high degree of selectivity over other family members.
USP1 is a protein regulating DNA damage response (DDR).
KSQ-4279 demonstrated efficacy both as a single agent and in combination with PARP inhibitors across multiple BRCA/HRD xenograft model.
