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Chemical Structure : KU-0063794
CAS No.: 938440-64-3
Catalog No.: PC-45851Not For Human Use, Lab Use Only.
KU-0063794 is a potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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KU-0063794 is a potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2.
KU-0063794 displays no activity against 76 other protein kinases or seven lipid kinases, including class 1 PI3Ks (>1,000-fold).
KU-0063794 suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK, also inhibits phosphorylation of the T-loop Thr308 of Akt, induces complete dephosphorylation of 4E-BP1 in HEK-293 cells.
KU-0063794 suppresses cell growth and induces G1-cell cycle arrest in both wild-type and mLST8 deficient MEFs.
| M.Wt | 465.5447 | |
| Formula | C25H31N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenemethanol, 5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-, rel- |
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1. García-Martínez JM, et al. Biochem J. 2009 Jun 12;421(1):29-42.
2. Malagu K, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5950-3.
3. Syed F, et al. J Invest Dermatol. 2013 May;133(5):1340-50.
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