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KU-32

Chemical Structure : KU-32

CAS No.: 956498-70-7

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KU-32 (KU 32;KU32)

Catalog No.: PC-60660Not For Human Use, Lab Use Only.

KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.
    KU-32 protects against neuronal death induced by amyloid β-peptide with minimally cytotoxic to primary cortical neurons.
    KU-32 significantly increases the expression of Hsp70 in MCF7 cells at 10 nM, decreases neurodegeneration of non-myelinated or myelinated sensory neurons in vitro and attenuates the pathophysiological progression of DPN in mice.

    Physicochemical Properties

    M.Wt 407.419
    Formula C20H25NO8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-{7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-2H-pyran-2-yloxy]-8-methyl-2-oxo-2H-chromen-3-yl}acetamide

    References

    1. Ma J, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):281-92.

    2. Urban MJ, et al. ASN Neuro. 2010 Aug 11;2(4):e00040.

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