Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-KU-32
KU-32

Chemical Structure : KU-32

CAS No.: 956498-70-7

Add to Favorites

KU-32 (KU 32;KU32)

Catalog No.: PC-60660Not For Human Use, Lab Use Only.

KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KU-32 is a novel, novobiocin-based, C-terminal inhibitor of Hsp90 and a potent inducer of Hsp70.
    KU-32 protects against neuronal death induced by amyloid β-peptide with minimally cytotoxic to primary cortical neurons.
    KU-32 significantly increases the expression of Hsp70 in MCF7 cells at 10 nM, decreases neurodegeneration of non-myelinated or myelinated sensory neurons in vitro and attenuates the pathophysiological progression of DPN in mice.

    Physicochemical Properties

    M.Wt 407.419
    Formula C20H25NO8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-{7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-2H-pyran-2-yloxy]-8-methyl-2-oxo-2H-chromen-3-yl}acetamide

    References

    1. Ma J, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):281-92.

    2. Urban MJ, et al. ASN Neuro. 2010 Aug 11;2(4):e00040.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: