Chemical Structure : KUNA-115
CAS No.:
2765823-77-4
KUNA-115
(KUNA115)
Catalog No.: PC-26413Not For Human Use, Lab Use Only.
KUNA-115 is a potent, selective Hsp90α inhibitor with IC50 of 0.84 uM in fluorescence polarization (FP) assays, >63-fold selective over Hsp90β.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KUNA-115 is a potent, selective Hsp90α inhibitor with IC50 of 0.84 uM in fluorescence polarization (FP) assays, >63-fold selective over Hsp90β.
KUNA-115 selectively inhibits cell growth of non-small cell lung cancer cell line, NCI-H522, melanoma cell line UACC-62, ovarian cancer cell line SK-OV-3, and renal cell carcinoma cell line UO-31.
KUNA-115 shows completely restrict cell permeability, retains Hsp90 isoform selectivity, does not induce intracellular Hsp90 client degradation, stimulation of the HSR or disruption of hERG channel maturation.
Physicochemical Properties
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M.Wt
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375.49
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Formula
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C23H21NO2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3-((3,4-dimethylphenyl)thio)-4-hydroxyphenyl)(isoindolin-2-yl)methanone
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References
1. Sanket J Mishra, et al. Angew Chem Int Ed Engl. 2021 May 3;60(19):10547-10551.
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