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KUNB31

Chemical Structure : KUNB31

CAS No.: 2220263-80-7

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KUNB31 (KUNB 31)

Catalog No.: PC-62516Not For Human Use, Lab Use Only.

KUNB31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KUNB31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94.
    KUNB31 exhibits anti-proliferative activity against NCI H23, UC3, and HT-29 cancer cell lines with IC50 of 6.74 µM, 3.01 µM, and 3.72 µM, respectively.
    KUNB31 specificly induces the degradation of Hsp90β-dependent client proteins (EGFR, HER2, CDK4, CDK6, CXCR4 etc.) in cells.

    Physicochemical Properties

    M.Wt 322.364
    Formula C19H18N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4-hydroxy-7-isopropylbenzo[d]isoxazol-5-yl)(isoindolin-2-yl)methanone

    References

    1. Khandelwal A, et al. Nat Commun. 2018 Jan 30;9(1):425.

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