KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo.
KW-2478 demonstrates antiproliferative activities against human MM cells, OPM-2/GFP, KMS-11, RPMI 8226, and NCI-H929 with IC50 of 0.30, 0.34, 0.39, and 0.12 uM respectively, associated with degradation of well-known client proteins as well as FGFR3, c-Maf, and cyclin D1.
KW-2478 suppresses tumor growth in NCI-H929 models.
