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Chemical Structure : KYA1797K
CAS No.: 1956356-56-1
Catalog No.: PC-70092Not For Human Use, Lab Use Only.
KYA1797K is a derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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KYA-1797K is a derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.
KYA-1797K dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation with IC50 of 0.75 uM.
KYA-1797K is more effectively reduces the levels of both β-catenin and pan-Ras as well as the activities of ERK and Akt in SW480 cells.
KYA-1797K binds to Axin (Kd to WT axin-RGS=0.29 uM) and destabilizes b-catenin and Ras; inhibits growth of CRC cells with GI50 of 4-5 uM.
KYA-1797K suppresses the tumors induced by APC and KRAS mutations in tumor xenograft mice (25 mg/kg, i.p.).
| M.Wt | 442.501 | |
| Formula | C17H11KN2O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate |
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1. Cha PH, et al. Nat Chem Biol. 2016 Aug;12(8):593-600.
2. Cha PH, et al. BMB Rep. 2016 Sep;49(9):455-6.
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